| Runs |
Out of |
4s |
6s |
| 84 | 119* | 15 | 4 | | SW Bates | Southern Vipers v Loughborough Lightning | The 3aaa County Ground, Derby | 2017 |
| 78 | 110 | 9 | 7 | | DN Wyatt | Southern Vipers v Surrey Stars | Arundel Castle Cricket Club Ground, Arundel | 2019 |
| 58 | 82 | 13 | 1 | | SW Bates | Southern Vipers v Surrey Stars | The 1st Central County Ground, Hove | 2018 |
| 52 | 73 | 10 | 2 | | DN Wyatt | Southern Vipers v Western Storm | The 1st Central County Ground, Hove | 2019 |
| 46 | 64 | 10 | 1 | | TT Beaumont | Southern Vipers v Yorkshire Diamonds | The Ageas Bowl, Southampton | 2018 |
| 40 | 62* | 10 | 0 | | TT Beaumont | Southern Vipers v Surrey Stars | Woodbridge Road, Guildford | 2018 |
| 40 | 54 | 10 | 0 | | DN Wyatt | Southern Vipers v Lancashire Thunder | Aigburth, Liverpool | 2019 |
| 44 | 56 | 8 | 2 | | DN Wyatt | Southern Vipers v Western Storm | County Ground, Bristol | 2019 |
| 46 | 59 | 7 | 3 | | DN Wyatt | Southern Vipers v Yorkshire Diamonds | The Ageas Bowl, Southampton | 2019 |
| 42 | 55* | 6 | 3 | | SJ McGlashan | Southern Vipers v Loughborough Lightning | Haslegrave Ground, Loughborough | 2018 |
| 40 | 42 | 7 | 2 | | DN Wyatt | Southern Vipers v Yorkshire Diamonds | Clifton Park, York | 2019 |
| 36 | 47* | 6 | 2 | | SW Bates | Southern Vipers v Western Storm | The Ageas Bowl, Southampton | 2017 |
| 34 | 46* | 7 | 1 | | DN Wyatt | Southern Vipers v Lancashire Thunder | Aigburth, Liverpool | 2017 |
| 32 | 48 | 8 | 0 | | M du Preez | Southern Vipers v Surrey Stars | Woodbridge Road, Guildford | 2018 |
| 28 | 41 | 7 | 0 | | GL Adams | Southern Vipers v Surrey Stars | The Ageas Bowl, Southampton | 2016 |
| 30 | 57 | 6 | 1 | | SW Bates | Southern Vipers v Western Storm | The Cooper Associates County Ground, Taunton | 2016 |
| 30 | 38 | 6 | 1 | | SW Bates | Southern Vipers v Loughborough Lightning | The Ageas Bowl, Southampton | 2016 |
| 28 | 52 | 7 | 0 | | SW Bates | Southern Vipers v Western Storm | The Essex County Ground, Chelmsford | 2016 |
| 28 | 50* | 7 | 0 | | SW Bates | Southern Vipers v Surrey Stars | The Ageas Bowl, Southampton | 2017 |
| 28 | 37 | 7 | 0 | | TT Beaumont | Southern Vipers v Loughborough Lightning | The Ageas Bowl, Southampton | 2018 |
| 28 | 39 | 7 | 0 | | DN Wyatt | Southern Vipers v Lancashire Thunder | Aigburth, Liverpool | 2018 |
| 28 | 34 | 7 | 0 | | SW Bates | Southern Vipers v Yorkshire Diamonds | Clifton Park, York | 2018 |
| 38 | 53 | 2 | 5 | | TT Beaumont | Southern Vipers v Lancashire Thunder | Aigburth, Liverpool | 2019 |
| 30 | 40 | 6 | 1 | | SR Taylor | Southern Vipers v Lancashire Thunder | Aigburth, Liverpool | 2019 |
| 28 | 40 | 7 | 0 | | DN Wyatt | Southern Vipers v Loughborough Lightning | Haslegrave Ground, Loughborough | 2019 |
| 28 | 44* | 7 | 0 | | SR Taylor | Southern Vipers v Western Storm | The Ageas Bowl, Southampton | 2019 |
| 30 | 37 | 6 | 1 | | SW Bates | Southern Vipers v Loughborough Lightning | The 1st Central County Ground, Hove | 2019 |
| 26 | 54* | 5 | 1 | | SJ McGlashan | Southern Vipers v Lancashire Thunder | Stanley Park, Blackpool | 2016 |
| 24 | 50* | 6 | 0 | | M du Preez | Southern Vipers v Yorkshire Diamonds | Arundel Castle Cricket Club Ground, Arundel | 2017 |
| 24 | 31 | 6 | 0 | | HK Matthews | Southern Vipers v Western Storm | The 1st Central County Ground, Hove | 2017 |
| 24 | 36 | 6 | 0 | | DN Wyatt | Southern Vipers v Loughborough Lightning | Haslegrave Ground, Loughborough | 2018 |
| 28 | 36 | 4 | 2 | | DN Wyatt | Southern Vipers v Lancashire Thunder | The Ageas Bowl, Southampton | 2018 |
| 28 | 51 | 4 | 2 | | SR Taylor | Southern Vipers v Lancashire Thunder | The 1st Central County Ground, Hove | 2019 |
| 24 | 47 | 6 | 0 | | SW Bates | Southern Vipers v Yorkshire Diamonds | Clifton Park, York | 2019 |
