| Runs |
Wkts |
| 754 | 15 | South Africa v Sri Lanka | Feroz Shah Kotla, Delhi | 2023/24 |
| 671 | 16 | Australia v South Africa | Warner Park, Basseterre | 2006/07 |
| 645 | 13 | West Indies v South Africa | Queen's Park (New), St George's | 2006/07 |
| 640 | 16 | Australia v South Africa | Emirates Old Trafford, Manchester | 2019 |
| 639 | 14 | Bangladesh v South Africa | The Kia Oval, Kennington | 2019 |
| 621 | 14 | Ireland v South Africa | Manuka Oval, Canberra | 2014/15 |
| 616 | 14 | South Africa v Zimbabwe | Seddon Park, Hamilton | 2014/15 |
| 615 | 15 | Bangladesh v South Africa | Wankhede Stadium, Mumbai | 2023/24 |
| 596 | 17 | India v South Africa | Vidarbha Cricket Association Stadium, Nagpur | 2010/11 |
| 580 | 11 | New Zealand v South Africa | Eden Park, Auckland | 2014/15 |
| 569 | 16 | England v South Africa | Wankhede Stadium, Mumbai | 2023/24 |
| 567 | 16 | Pakistan v South Africa | Lord's Cricket Ground, St John's Wood | 2019 |
| 559 | 15 | South Africa v West Indies | Sydney Cricket Ground, Sydney | 2014/15 |
| 553 | 14 | South Africa v West Indies | Newlands, Cape Town | 2002/03 |
| 543 | 12 | Australia v South Africa | Headingley, Leeds | 1999 |
| 541 | 19 | Pakistan v South Africa | MA Chidambaram Stadium, Chepauk, Chennai | 2023/24 |
| 536 | 15 | South Africa v United Arab Emirates | Westpac Stadium, Wellington | 2014/15 |
| 535 | 7 | South Africa v New Zealand | New Wanderers Stadium, Johannesburg | 2002/03 |
| 524 | 14 | New Zealand v South Africa | Maharashtra Cricket Association Stadium, Gahunje | 2023/24 |
| 518 | 18 | England v South Africa | The Kia Oval, Kennington | 2019 |
| 509 | 18 | South Africa v West Indies | National Stadium, Karachi | 1995/96 |
| 507 | 11 | India v South Africa | County Ground, Hove | 1999 |
| 500 | 13 | New Zealand v South Africa | Edgbaston, Birmingham | 1999 |
| 497 | 15 | South Africa v Sri Lanka | Kingsmead, Durban | 2002/03 |
| 496 | 11 | Netherlands v South Africa | Rawalpindi Cricket Stadium, Rawalpindi | 1995/96 |
| 491 | 15 | Afghanistan v South Africa | Narendra Modi Stadium, Motera, Ahmedabad | 2023/24 |
| 488 | 17 | Australia v South Africa | Bharat Ratna Shri Atal Bihari Vajpayee Ekana Cricket Stadium, Lucknow | 2023/24 |
| 486 | 12 | New Zealand v South Africa | Edgbaston, Birmingham | 2019 |
| 485 | 11 | Pakistan v South Africa | National Stadium, Karachi | 1995/96 |
| 485 | 12 | Netherlands v South Africa | Warner Park, Basseterre | 2006/07 |
