| Runs |
Out of |
4s |
6s |
| 116 | 162* | 17 | 8 | | AB de Villiers | South Africa v West Indies | Sydney Cricket Ground, Sydney | 2014/15 |
| 94 | 143 | 19 | 3 | | HH Gibbs | South Africa v New Zealand | New Wanderers Stadium, Johannesburg | 2002/03 |
| 102 | 174 | 15 | 7 | | Q de Kock | South Africa v Bangladesh | Wankhede Stadium, Mumbai | 2023/24 |
| 88 | 159 | 16 | 4 | | HM Amla | South Africa v Ireland | Manuka Oval, Canberra | 2014/15 |
| 76 | 188* | 13 | 4 | | G Kirsten | South Africa v United Arab Emirates | Rawalpindi Cricket Stadium, Rawalpindi | 1995/96 |
| 76 | 161 | 13 | 4 | | AC Hudson | South Africa v Netherlands | Rawalpindi Cricket Stadium, Rawalpindi | 1995/96 |
| 78 | 146 | 12 | 5 | | AB de Villiers | South Africa v West Indies | Queen's Park (New), St George's | 2006/07 |
| 76 | 134 | 13 | 4 | | AB de Villiers | South Africa v Netherlands | Punjab Cricket Association Stadium, Mohali | 2010/11 |
| 74 | 106 | 14 | 3 | | AK Markram | South Africa v Sri Lanka | Feroz Shah Kotla, Delhi | 2023/24 |
| 72 | 87* | 12 | 4 | | HH Gibbs | South Africa v Kenya | North West Cricket Stadium, Potchefstroom | 2002/03 |
| 74 | 128* | 11 | 5 | | JH Kallis | South Africa v Netherlands | Warner Park, Basseterre | 2006/07 |
| 68 | 92 | 14 | 2 | | AB de Villiers | South Africa v Australia | Warner Park, Basseterre | 2006/07 |
| 82 | 138* | 7 | 9 | | DA Miller | South Africa v Zimbabwe | Seddon Park, Hamilton | 2014/15 |
| 72 | 109 | 12 | 4 | | H Klaasen | South Africa v England | Wankhede Stadium, Mumbai | 2023/24 |
| 66 | 100 | 12 | 3 | | Q de Kock | South Africa v Sri Lanka | Feroz Shah Kotla, Delhi | 2023/24 |
| 64 | 108 | 13 | 2 | | HE van der Dussen | South Africa v Sri Lanka | Feroz Shah Kotla, Delhi | 2023/24 |
| 62 | 78 | 11 | 3 | | WJ Cronje | South Africa v New Zealand | Iqbal Stadium, Faisalabad | 1995/96 |
| 58 | 91 | 13 | 1 | | GC Smith | South Africa v Scotland | Warner Park, Basseterre | 2006/07 |
| 66 | 133 | 9 | 5 | | HE van der Dussen | South Africa v New Zealand | Maharashtra Cricket Association Stadium, Gahunje | 2023/24 |
| 60 | 75* | 9 | 4 | | MV Boucher | South Africa v Netherlands | Warner Park, Basseterre | 2006/07 |
| 52 | 89* | 13 | 0 | | GC Smith | South Africa v England | Kensington Oval, Bridgetown | 2006/07 |
| 62 | 109 | 8 | 5 | | Q de Kock | South Africa v Australia | Bharat Ratna Shri Atal Bihari Vajpayee Ekana Cricket Stadium, Lucknow | 2023/24 |
| 58 | 114 | 10 | 3 | | Q de Kock | South Africa v New Zealand | Maharashtra Cricket Association Stadium, Gahunje | 2023/24 |
| 62 | 101 | 8 | 5 | | DA Miller | South Africa v Australia | Eden Gardens, Kolkata | 2023/24 |
| 54 | 115* | 9 | 3 | | JP Duminy | South Africa v Zimbabwe | Seddon Park, Hamilton | 2014/15 |
| 58 | 77 | 7 | 5 | | AB de Villiers | South Africa v Pakistan | Eden Park, Auckland | 2014/15 |
| 48 | 78* | 12 | 0 | | Q de Kock | South Africa v Sri Lanka | Sydney Cricket Ground, Sydney | 2014/15 |
| 54 | 85 | 9 | 3 | | RR Hendricks | South Africa v England | Wankhede Stadium, Mumbai | 2023/24 |
| 46 | 101 | 10 | 1 | | HH Gibbs | South Africa v Australia | Headingley, Leeds | 1999 |
| 58 | 72 | 4 | 7 | | HH Gibbs | South Africa v Netherlands | Warner Park, Basseterre | 2006/07 |
| 48 | 62 | 9 | 2 | | AB de Villiers | South Africa v Scotland | Warner Park, Basseterre | 2006/07 |
| 48 | 74 | 9 | 2 | | GC Smith | South Africa v Australia | Warner Park, Basseterre | 2006/07 |
| 46 | 109 | 10 | 1 | | F du Plessis | South Africa v Ireland | Manuka Oval, Canberra | 2014/15 |
| 46 | 96* | 10 | 1 | | F du Plessis | South Africa v Sri Lanka | Emirates Riverside, Chester-le-Street | 2019 |
