| Runs |
Out of |
4s |
6s |
| 82 | 101 | 16 | 3 | | L Lee | South Africa Women v Thailand Women | Manuka Oval, Canberra | 2019/20 |
| 66 | 84 | 15 | 1 | | L Lee | South Africa Women v India Women | Lalabhai Contractor Stadium, Surat | 2019/20 |
| 66 | 102 | 12 | 3 | | L Wolvaardt | South Africa Women v Sri Lanka Women | Willowmoore Park Main Oval, Benoni | 2023/24 |
| 60 | 116* | 12 | 2 | | SA Fritz | South Africa Women v Netherlands Women | Absa Puk Oval, Potchefstroom | 2010/11 |
| 58 | 90* | 13 | 1 | | D van Niekerk | South Africa Women v Pakistan Women | Sylhet Stadium, Sylhet | 2013/14 |
| 54 | 69 | 12 | 1 | | M du Preez | South Africa Women v Ireland Women | Scorers, Shirley | 2014 |
| 52 | 71* | 13 | 0 | | D van Niekerk | South Africa Women v Sri Lanka Women | PPC Newlands, Cape Town | 2018/19 |
| 56 | 75* | 11 | 2 | | L Lee | South Africa Women v Pakistan Women | Willowmoore Park Main Oval, Benoni | 2019 |
| 54 | 75 | 12 | 1 | | L Lee | South Africa Women v West Indies Women | Sir Vivian Richards Stadium, North Sound | 2021 |
| 58 | 81 | 10 | 3 | | T Brits | South Africa Women v India Women | MA Chidambaram Stadium, Chepauk, Chennai | 2024 |
| 60 | 98* | 9 | 4 | | T Brits | South Africa Women v West Indies Women | Three Ws Oval, Cave Hill | 2025 |
| 50 | 66 | 11 | 1 | | D van Niekerk | South Africa Women v Bangladesh Women | Mangaung Oval, Bloemfontein | 2018 |
| 50 | 70 | 11 | 1 | | L Lee | South Africa Women v India Women | Bharat Ratna Shri Atal Bihari Vajpayee Ekana Cricket Stadium, Lucknow | 2020/21 |
| 50 | 72 | 8 | 3 | | D van Niekerk | South Africa Women v England Women | The Cooper Associates County Ground, Taunton | 2018 |
| 44 | 60 | 11 | 0 | | L Lee | South Africa Women v Pakistan Women | Willowmoore Park Main Oval, Benoni | 2019 |
| 46 | 75 | 10 | 1 | | M Kapp | South Africa Women v Australia Women | Blundstone Arena, Hobart | 2023/24 |
| 44 | 69* | 8 | 2 | | L Lee | South Africa Women v England Women | Bidvest Wanderers Stadium, Johannesburg | 2015/16 |
| 42 | 58 | 9 | 1 | | D van Niekerk | South Africa Women v New Zealand Women | The Cooper Associates County Ground, Taunton | 2018 |
| 52 | 68 | 4 | 6 | | L Lee | South Africa Women v England Women | The Cooper Associates County Ground, Taunton | 2018 |
| 40 | 42 | 10 | 0 | | L Lee | South Africa Women v West Indies Women | Brian Lara Stadium, Tarouba | 2018/19 |
| 42 | 70* | 9 | 1 | | T Brits | South Africa Women v Pakistan Women | City Oval, Pietermaritzburg | 2019 |
| 42 | 66* | 9 | 1 | | AE Bosch | South Africa Women v India Women | Bharat Ratna Shri Atal Bihari Vajpayee Ekana Cricket Stadium, Lucknow | 2020/21 |
| 42 | 78 | 9 | 1 | | T Brits | South Africa Women v Pakistan Women | National Bank Cricket Arena, Karachi | 2023/24 |
| 42 | 67 | 9 | 1 | | AE Bosch | South Africa Women v Bangladesh Women | Willowmoore Park Main Oval, Benoni | 2023/24 |
| 38 | 67* | 8 | 1 | | L Lee | South Africa Women v Pakistan Women | Sylhet Stadium, Sylhet | 2013/14 |
| 40 | 70* | 7 | 2 | | D van Niekerk | South Africa Women v Sri Lanka Women | Mercantile Cricket Association Ground, Colombo | 2014/15 |
| 40 | 63 | 7 | 2 | | D van Niekerk | South Africa Women v England Women | PPC Newlands, Cape Town | 2015/16 |
| 36 | 71 | 9 | 0 | | SE Luus | South Africa Women v Bangladesh Women | Mangaung Oval, Bloemfontein | 2018 |
| 38 | 66 | 8 | 1 | | T Brits | South Africa Women v Pakistan Women | Hollywoodbets Kingsmead, Durban | 2020/21 |
| 36 | 48 | 9 | 0 | | L Goodall | South Africa Women v Ireland Women | Sydney Parade, Dublin | 2022 |
| 36 | 72 | 9 | 0 | | L Wolvaardt | South Africa Women v Pakistan Women | National Bank Cricket Arena, Karachi | 2023/24 |
| 38 | 57 | 8 | 1 | | M Kapp | South Africa Women v India Women | MA Chidambaram Stadium, Chepauk, Chennai | 2024 |
| 38 | 74* | 8 | 1 | | AE Bosch | South Africa Women v Australia Women | Dubai Sports City Stadium, Dubai | 2024/25 |
