| Runs |
Wkts |
| 459 | 12 | England v South Africa | Wankhede Stadium, Mumbai | 2015/16 |
| 413 | 8 | South Africa v West Indies | Liberty Life Wanderers Stadium, Johannesburg | 2007/08 |
| 389 | 12 | England v South Africa | Zohur Ahmed Chowdhury Stadium, Chittagong | 2013/14 |
| 381 | 15 | Afghanistan v South Africa | Wankhede Stadium, Mumbai | 2015/16 |
| 370 | 10 | South Africa v United States of America | Sir Vivian Richards Stadium, North Sound | 2024 |
| 368 | 10 | England v South Africa | Sharjah Cricket Association Stadium, Sharjah | 2021/22 |
| 358 | 10 | India v South Africa | Beausejour Stadium, Gros Islet | 2010 |
| 348 | 8 | India v South Africa | Shere Bangla National Stadium, Mirpur | 2013/14 |
| 346 | 16 | South Africa v West Indies | The Brit Oval, Kennington | 2009 |
| 345 | 15 | India v South Africa | Kensington Oval, Bridgetown | 2024 |
| 338 | 14 | New Zealand v South Africa | Zohur Ahmed Chowdhury Stadium, Chittagong | 2013/14 |
| 327 | 11 | New Zealand v South Africa | Kensington Oval, Bridgetown | 2010 |
| 325 | 15 | South Africa v Sri Lanka | Zohur Ahmed Chowdhury Stadium, Chittagong | 2013/14 |
| 319 | 12 | England v South Africa | Daren Sammy National Cricket Stadium, Gros Islet | 2024 |
| 311 | 12 | South Africa v New Zealand | Sahara Stadium Kingsmead, Durban | 2007/08 |
| 306 | 15 | Bangladesh v South Africa | Sydney Cricket Ground, Sydney | 2022/23 |
| 303 | 16 | India v South Africa | R Premadasa Stadium, Colombo | 2012/13 |
| 303 | 12 | Netherlands v South Africa | Adelaide Oval, Adelaide | 2022/23 |
| 297 | 17 | England v South Africa | Kensington Oval, Bridgetown | 2010 |
| 293 | 7 | Australia v South Africa | R Premadasa Stadium, Colombo | 2012/13 |
| 293 | 18 | Pakistan v South Africa | Sydney Cricket Ground, Sydney | 2022/23 |
| 292 | 15 | Scotland v South Africa | The Brit Oval, Kennington | 2009 |
| 291 | 9 | Pakistan v South Africa | Trent Bridge, Nottingham | 2009 |
| 290 | 13 | South Africa v Bangladesh | Sahara Park Newlands, Cape Town | 2007/08 |
| 289 | 15 | South Africa v England | Sahara Park Newlands, Cape Town | 2007/08 |
| 288 | 16 | South Africa v Sri Lanka | Sharjah Cricket Association Stadium, Sharjah | 2021/22 |
| 287 | 10 | South Africa v West Indies | Dubai Sports City Stadium, Dubai | 2021/22 |
| 285 | 14 | Pakistan v South Africa | Beausejour Stadium, Gros Islet | 2010 |
| 284 | 19 | Netherlands v South Africa | Zohur Ahmed Chowdhury Stadium, Chittagong | 2013/14 |
| 270 | 14 | India v South Africa | Optus Stadium, Perth | 2022/23 |
