| Runs |
Wkts |
| 674 | 15 | New Zealand v South Africa | Gaddafi Stadium, Lahore | 2024/25 |
| 636 | 17 | India v South Africa | The SWALEC Stadium, Cardiff | 2013 |
| 624 | 17 | South Africa v England | SuperSport Park, Centurion | 2009/10 |
| 564 | 11 | England v South Africa | Bangabandhu National Stadium, Dhaka | 1998/99 |
| 525 | 15 | South Africa v Sri Lanka | SuperSport Park, Centurion | 2009/10 |
| 523 | 16 | Afghanistan v South Africa | National Bank Cricket Arena, Karachi | 2024/25 |
| 520 | 12 | South Africa v West Indies | Sawai Mansingh Stadium, Jaipur | 2006/07 |
| 512 | 15 | India v South Africa | R Premadasa Stadium, Colombo | 2002/03 |
| 502 | 16 | South Africa v Sri Lanka | The Kia Oval, Kennington | 2017 |
| 495 | 16 | India v South Africa | Gymkhana Club Ground, Nairobi | 2000/01 |
| 495 | 11 | South Africa v West Indies | The Brit Oval, Kennington | 2004 |
| 493 | 16 | South Africa v West Indies | Bangabandhu National Stadium, Dhaka | 1998/99 |
| 480 | 16 | South Africa v West Indies | Sinhalese Sports Club Ground, Colombo | 2002/03 |
| 456 | 15 | Kenya v South Africa | R Premadasa Stadium, Colombo | 2002/03 |
| 431 | 15 | South Africa v New Zealand | SuperSport Park, Centurion | 2009/10 |
| 420 | 12 | South Africa v West Indies | The SWALEC Stadium, Cardiff | 2013 |
| 401 | 19 | Pakistan v South Africa | Edgbaston, Birmingham | 2013 |
| 384 | 12 | India v South Africa | The Kia Oval, Kennington | 2017 |
| 372 | 16 | South Africa v Sri Lanka | Bangabandhu National Stadium, Dhaka | 1998/99 |
| 366 | 12 | England v South Africa | Gymkhana Club Ground, Nairobi | 2000/01 |
| 360 | 19 | South Africa v Sri Lanka | Sardar Patel Stadium, Motera, Ahmedabad | 2006/07 |
| 360 | 13 | England v South Africa | National Bank Cricket Arena, Karachi | 2024/25 |
| 354 | 13 | England v South Africa | The Kia Oval, Kennington | 2013 |
| 338 | 11 | Pakistan v South Africa | Edgbaston, Birmingham | 2017 |
| 303 | 20 | New Zealand v South Africa | Brabourne Stadium, Mumbai | 2006/07 |
| 302 | 18 | Pakistan v South Africa | Punjab Cricket Association Stadium, Mohali | 2006/07 |
| 187 | 11 | Bangladesh v South Africa | Edgbaston, Birmingham | 2004 |
