Most Runs in a Season for Multan Sultans
| 550 | Mohammad Rizwan | 2022/23 |
| 546 | Mohammad Rizwan | 2021/22 |
| 478 | Shan Masood | 2021/22 |
| 453 | RR Rossouw | 2022/23 |
| 430 | Usman Khan | 2023/24 |
| 407 | Mohammad Rizwan | 2023/24 |
| 367 | Mohammad Rizwan | 2024/25 |
| 304 | RR Hendricks | 2023/24 |
| 297 | Mohammad Rizwan | 2020/21 |
| 293 | Sohaib Maqsood | 2021 |
| 278 | TH David | 2021/22 |
| 275 | RR Rossouw | 2021/22 |
| 269 | KC Sangakkara | 2017/18 |
| 266 | Shoaib Malik | 2018/19 |
| 260 | KA Pollard | 2022/23 |
| 259 | Iftikhar Ahmed | 2023/24 |
| 254 | Shan Masood | 2019/20 |
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