| Runs |
Wkts |
| 506 | 10 | Surrey v Middlesex | The Kia Oval, Kennington | 2023 |
| 464 | 10 | Somerset v Middlesex | The Cooper Associates County Ground, Taunton | 2025 |
| 453 | 9 | Somerset v Middlesex | The Cooper Associates County Ground, Taunton | 2019 |
| 451 | 14 | Essex v Middlesex | The Cloud County Ground, Chelmsford | 2023 |
| 447 | 8 | Middlesex v Glamorgan | Merchant Taylors' School Ground, Northwood | 2023 |
| 443 | 6 | Surrey v Middlesex | The Kia Oval, Kennington | 2018 |
| 443 | 10 | Middlesex v Kent | Lord's Cricket Ground, St John's Wood | 2023 |
| 432 | 13 | Middlesex v Hampshire | Brunton Memorial Ground, Radlett | 2021 |
| 430 | 14 | Somerset v Middlesex | County Ground, Taunton | 2011 |
| 428 | 18 | Middlesex v Gloucestershire | Brunton Memorial Ground, Radlett | 2022 |
| 421 | 7 | Middlesex v Essex | Lord's Cricket Ground, St John's Wood | 2018 |
| 418 | 9 | Middlesex v Kent | Lord's Cricket Ground, St John's Wood | 2020 |
| 414 | 10 | Gloucestershire v Middlesex | Brightside Ground, Bristol | 2018 |
| 410 | 13 | Essex v Middlesex | The Cloud County Ground, Chelmsford | 2024 |
| 406 | 10 | Middlesex v Surrey | Lord's Cricket Ground, St John's Wood | 2020 |
| 403 | 11 | Middlesex v Gloucestershire | Uxbridge Cricket Club Ground, Uxbridge | 2011 |
| 403 | 12 | Somerset v Middlesex | The Cooper Associates County Ground, Taunton | 2018 |
| 402 | 13 | Hampshire v Middlesex | The Rose Bowl, Southampton | 2005 |
| 401 | 13 | Kent v Middlesex | Spitfire Ground, St Lawrence, Canterbury | 2023 |
| 400 | 14 | Kent v Middlesex | Spitfire Ground, St Lawrence, Canterbury | 2014 |
| 400 | 11 | Sussex v Middlesex | The Brighton and Hove Jobs County Ground, Hove | 2015 |
| 399 | 15 | Sussex v Middlesex | The 1st Central County Ground, Hove | 2018 |
| 399 | 12 | Gloucestershire v Middlesex | Seat Unique Stadium, Bristol | 2025 |
| 396 | 14 | Middlesex v Surrey | Lord's Cricket Ground, St John's Wood | 2006 |
| 396 | 11 | Middlesex v Surrey | Lord's Cricket Ground, St John's Wood | 2016 |
| 396 | 15 | Middlesex v Surrey | Lord's Cricket Ground, St John's Wood | 2022 |
| 395 | 14 | Middlesex v Essex | Lord's Cricket Ground, St John's Wood | 2010 |
| 395 | 14 | Middlesex v Somerset | Old Deer Park, Richmond | 2019 |
| 393 | 16 | Middlesex v Somerset | Uxbridge Cricket Club Ground, Uxbridge | 2017 |
| 392 | 16 | Middlesex v Surrey | Lord's Cricket Ground, St John's Wood | 2021 |
