| Runs |
Out of |
4s |
6s |
| 108 | 129 | 12 | 10 | | DT Christian | Middlesex v Kent | Spitfire Ground, St Lawrence, Canterbury | 2014 |
| 86 | 117 | 11 | 7 | | DJ Malan | Middlesex v Surrey | The Kia Oval, Kennington | 2019 |
| 82 | 106 | 10 | 7 | | AC Gilchrist | Middlesex v Kent | St Lawrence Ground, Canterbury | 2010 |
| 74 | 115* | 14 | 3 | | DJ Malan | Middlesex v Sussex | The Brighton and Hove Jobs County Ground, Hove | 2015 |
| 76 | 103 | 10 | 6 | | DJ Malan | Middlesex v Lancashire | The Brit Oval, Kennington | 2008 |
| 78 | 109 | 9 | 7 | | PR Stirling | Middlesex v Surrey | The Kia Oval, Kennington | 2018 |
| 66 | 91* | 15 | 1 | | SS Eskinazi | Middlesex v Glamorgan | Brunton Memorial Ground, Radlett | 2021 |
| 76 | 121* | 10 | 6 | | MDE Holden | Middlesex v Kent | Lord's Cricket Ground, St John's Wood | 2023 |
| 70 | 93 | 10 | 5 | | DJ Malan | Middlesex v Hampshire | Uxbridge Cricket Club Ground, Uxbridge | 2016 |
| 72 | 88 | 9 | 6 | | BB McCullum | Middlesex v Kent | Old Deer Park, Richmond | 2017 |
| 64 | 87 | 13 | 2 | | SS Eskinazi | Middlesex v Gloucestershire | Brunton Memorial Ground, Radlett | 2022 |
| 66 | 94 | 12 | 3 | | SS Eskinazi | Middlesex v Hampshire | Merchant Taylors' School Ground, Northwood | 2025 |
| 64 | 74 | 10 | 4 | | AM Rossington | Middlesex v Kent | Uxbridge Cricket Club Ground, Uxbridge | 2013 |
| 64 | 98* | 10 | 4 | | JL Denly | Middlesex v Somerset | The Kia Oval, Kennington | 2014 |
| 64 | 88 | 10 | 4 | | PR Stirling | Middlesex v Sussex | The Brighton and Hove Jobs County Ground, Hove | 2015 |
| 58 | 73 | 13 | 1 | | SS Eskinazi | Middlesex v Surrey | The Kia Oval, Kennington | 2023 |
| 58 | 86 | 10 | 3 | | DJ Malan | Middlesex v Essex | Lord's Cricket Ground, St John's Wood | 2013 |
| 60 | 77 | 9 | 4 | | EJG Morgan | Middlesex v Essex | Lord's Cricket Ground, St John's Wood | 2014 |
| 66 | 90 | 6 | 7 | | PR Stirling | Middlesex v Kent | Lord's Cricket Ground, St John's Wood | 2015 |
| 60 | 90 | 9 | 4 | | EJG Morgan | Middlesex v Sussex | Lord's Cricket Ground, St John's Wood | 2018 |
| 68 | 83* | 5 | 8 | | EJG Morgan | Middlesex v Somerset | The Cooper Associates County Ground, Taunton | 2019 |
| 56 | 102* | 11 | 2 | | SS Eskinazi | Middlesex v Essex | Lord's Cricket Ground, St John's Wood | 2021 |
| 58 | 77 | 10 | 3 | | JB Cracknell | Middlesex v Glamorgan | Merchant Taylors' School Ground, Northwood | 2023 |
| 62 | 85* | 8 | 5 | | MDE Holden | Middlesex v Essex | The Cloud County Ground, Chelmsford | 2024 |
| 54 | 87* | 12 | 1 | | MDE Holden | Middlesex v Somerset | The Cooper Associates County Ground, Taunton | 2025 |
| 56 | 72 | 8 | 4 | | OA Shah | Middlesex v Hampshire | The Rose Bowl, Southampton | 2005 |
| 58 | 78 | 7 | 5 | | OA Shah | Middlesex v Surrey | Lord's Cricket Ground, St John's Wood | 2005 |
| 58 | 79* | 7 | 5 | | EJG Morgan | Middlesex v Glamorgan | Old Deer Park, Richmond | 2010 |
| 50 | 90* | 11 | 1 | | JL Denly | Middlesex v Kent | St Lawrence Ground, Canterbury | 2012 |
| 52 | 66 | 10 | 2 | | PR Stirling | Middlesex v Surrey | Lord's Cricket Ground, St John's Wood | 2018 |
| 56 | 78 | 8 | 4 | | PR Stirling | Middlesex v Essex | Lord's Cricket Ground, St John's Wood | 2018 |
| 54 | 102* | 9 | 3 | | MDE Holden | Middlesex v Essex | The Cloudfm County Ground, Chelmsford | 2020 |
| 54 | 77 | 9 | 3 | | JB Cracknell | Middlesex v Hampshire | Brunton Memorial Ground, Radlett | 2021 |
| 48 | 59 | 12 | 0 | | SS Eskinazi | Middlesex v Glamorgan | Merchant Taylors' School Ground, Northwood | 2023 |
