| Runs |
Wkts |
| 453 | 13 | Lancashire v Yorkshire | Emirates Old Trafford, Manchester | 2025 |
| 434 | 11 | Durham v Lancashire | Seat Unique Riverside Ground, Chester-le-Street | 2024 |
| 433 | 12 | Lancashire v Yorkshire | Emirates Old Trafford, Manchester | 2015 |
| 422 | 13 | Yorkshire v Lancashire | Headingley, Leeds | 2022 |
| 421 | 11 | Lancashire v Derbyshire | Emirates Old Trafford, Manchester | 2022 |
| 415 | 14 | Lancashire v Derbyshire | Emirates Old Trafford, Manchester | 2014 |
| 412 | 11 | Surrey v Lancashire | The Brit Oval, Kennington | 2005 |
| 412 | 11 | Lancashire v Yorkshire | Edgbaston, Birmingham | 2022 |
| 411 | 12 | Worcestershire v Lancashire | Blackfinch New Road, Worcester | 2019 |
| 408 | 11 | Worcestershire v Lancashire | County Ground, New Road, Worcester | 2014 |
| 406 | 17 | Derbyshire v Lancashire | The Central Co-op County Ground, Derby | 2025 |
| 405 | 7 | Leicestershire v Lancashire | Fischer County Ground, Grace Road, Leicester | 2016 |
| 404 | 15 | Lancashire v Northamptonshire | Emirates Old Trafford, Manchester | 2024 |
| 403 | 7 | Hampshire v Lancashire | The Ageas Bowl, Southampton | 2013 |
| 398 | 13 | Worcestershire v Lancashire | County Ground, New Road, Worcester | 2016 |
| 394 | 9 | Lancashire v Nottinghamshire | Emirates Old Trafford, Manchester | 2023 |
| 393 | 8 | Derbyshire v Lancashire | The Incora County Ground, Derby | 2021 |
| 392 | 10 | Lancashire v Durham | Emirates Old Trafford, Manchester | 2021 |
| 389 | 13 | Worcestershire v Lancashire | County Ground, New Road, Worcester | 2010 |
| 387 | 14 | Derbyshire v Lancashire | The 3aaa County Ground, Derby | 2017 |
| 385 | 13 | Lancashire v Nottinghamshire | Emirates Old Trafford, Manchester | 2025 |
| 384 | 12 | Derbyshire v Lancashire | County Ground, Derby | 2009 |
| 384 | 10 | Lancashire v Leicestershire | Emirates Old Trafford, Manchester | 2018 |
| 382 | 14 | Lancashire v Yorkshire | Emirates Old Trafford, Manchester | 2016 |
| 380 | 12 | Warwickshire v Lancashire | Edgbaston, Birmingham | 2007 |
| 380 | 11 | Derbyshire v Lancashire | County Ground, Derby | 2011 |
| 379 | 11 | Lancashire v Durham | Old Trafford, Manchester | 2005 |
| 378 | 11 | Lancashire v Worcestershire | Emirates Old Trafford, Manchester | 2018 |
| 376 | 8 | Lancashire v Worcestershire | Emirates Old Trafford, Manchester | 2014 |
| 375 | 14 | Yorkshire v Lancashire | Headingley, Leeds | 2023 |
