| Runs |
Out of |
4s |
6s |
| 72 | 92* | 12 | 4 | | SG Law | Lancashire v Leicestershire | Old Trafford, Manchester | 2005 |
| 78 | 100 | 9 | 7 | | LS Livingstone | Lancashire v Derbyshire | The 3aaa County Ground, Derby | 2018 |
| 66 | 101 | 12 | 3 | | SG Law | Lancashire v Yorkshire | Old Trafford, Manchester | 2005 |
| 70 | 100 | 10 | 5 | | MB Loye | Lancashire v Durham | Old Trafford, Manchester | 2005 |
| 64 | 78* | 13 | 2 | | F du Plessis | Lancashire v Leicestershire | Grace Road, Leicester | 2009 |
| 72 | 93 | 9 | 6 | | A Flintoff | Lancashire v Derbyshire | County Ground, Derby | 2009 |
| 60 | 73 | 12 | 2 | | MB Loye | Lancashire v Derbyshire | Old Trafford, Manchester | 2005 |
| 62 | 102* | 11 | 3 | | L Vincent | Lancashire v Derbyshire | Old Trafford, Manchester | 2008 |
| 64 | 88 | 10 | 4 | | SJ Croft | Lancashire v Worcestershire | County Ground, New Road, Worcester | 2010 |
| 64 | 103* | 10 | 4 | | AN Petersen | Lancashire v Leicestershire | Fischer County Ground, Grace Road, Leicester | 2016 |
| 68 | 83 | 8 | 6 | | JC Buttler | Lancashire v Derbyshire | Emirates Old Trafford, Manchester | 2023 |
| 68 | 95 | 8 | 6 | | KK Jennings | Lancashire v Nottinghamshire | Emirates Old Trafford, Manchester | 2025 |
| 58 | 85 | 10 | 3 | | A Flintoff | Lancashire v Yorkshire | Headingley, Leeds | 2004 |
| 54 | 66* | 12 | 1 | | SC Moore | Lancashire v Yorkshire | Emirates Old Trafford, Manchester | 2013 |
| 64 | 79 | 7 | 6 | | LS Livingstone | Lancashire v Yorkshire | Emirates Old Trafford, Manchester | 2018 |
| 56 | 94* | 11 | 2 | | AL Davies | Lancashire v Leicestershire | Emirates Old Trafford, Manchester | 2018 |
| 58 | 108 | 10 | 3 | | KK Jennings | Lancashire v Durham | Emirates Riverside, Chester-le-Street | 2020 |
| 52 | 83* | 13 | 0 | | AL Davies | Lancashire v Derbyshire | The Incora County Ground, Derby | 2021 |
| 64 | 87 | 7 | 6 | | LWP Wells | Lancashire v Nottinghamshire | Emirates Old Trafford, Manchester | 2025 |
| 68 | 83 | 5 | 8 | | LWP Wells | Lancashire v Derbyshire | The Central Co-op County Ground, Derby | 2025 |
| 56 | 90* | 8 | 4 | | BJ Hodge | Lancashire v Derbyshire | County Ground, Derby | 2005 |
| 52 | 89 | 10 | 2 | | MB Loye | Lancashire v Durham | Riverside Ground, Chester-le-Street | 2007 |
| 54 | 83* | 9 | 3 | | SJ Croft | Lancashire v Nottinghamshire | Trent Bridge, Nottingham | 2009 |
| 56 | 79 | 8 | 4 | | GJ Maxwell | Lancashire v Warwickshire | Edgbaston, Birmingham | 2019 |
| 60 | 94 | 6 | 6 | | SJ Croft | Lancashire v Worcestershire | Blackfinch New Road, Worcester | 2019 |
| 52 | 94* | 10 | 2 | | LS Livingstone | Lancashire v Derbyshire | Emirates Old Trafford, Manchester | 2021 |
| 54 | 66 | 9 | 3 | | LWP Wells | Lancashire v Derbyshire | Edgbaston, Birmingham | 2023 |
| 62 | 101 | 5 | 7 | | SJ Croft | Lancashire v Northamptonshire | County Ground, Northampton | 2023 |
| 56 | 80 | 8 | 4 | | PD Salt | Lancashire v Northamptonshire | County Ground, Northampton | 2025 |
| 56 | 92* | 5 | 6 | | TC Smith | Lancashire v Worcestershire | Old Trafford, Manchester | 2010 |
| 46 | 59 | 10 | 1 | | SC Moore | Lancashire v Yorkshire | Old Trafford, Manchester | 2010 |
| 48 | 71* | 9 | 2 | | PJ Horton | Lancashire v Worcestershire | Emirates Old Trafford, Manchester | 2014 |
| 48 | 68 | 9 | 2 | | AG Prince | Lancashire v Worcestershire | County Ground, New Road, Worcester | 2014 |
| 48 | 94* | 9 | 2 | | SJ Croft | Lancashire v Derbyshire | Emirates Old Trafford, Manchester | 2015 |
| 46 | 72 | 10 | 1 | | MJ Guptill | Lancashire v Durham | Emirates Old Trafford, Manchester | 2016 |
| 52 | 57 | 7 | 4 | | JC Buttler | Lancashire v Worcestershire | County Ground, New Road, Worcester | 2016 |
| 50 | 66 | 8 | 3 | | FH Allen | Lancashire v Durham | Emirates Old Trafford, Manchester | 2021 |
| 50 | 77 | 8 | 3 | | JC Buttler | Lancashire v Yorkshire | Headingley, Leeds | 2025 |
| 58 | 85* | 4 | 7 | | LS Livingstone | Lancashire v Kent | Emirates Old Trafford, Manchester | 2025 |
