| Runs |
Wkts |
| 492 | 17 | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Warner Park, Basseterre | 2024 |
| 415 | 12 | Guyana Amazon Warriors v Jamaica Tallawahs | Guyana National Stadium, Providence | 2022 |
| 406 | 11 | Guyana Amazon Warriors v Barbados Tridents | Guyana National Stadium, Providence | 2019 |
| 405 | 8 | Antigua Hawksbills v Guyana Amazon Warriors | Warner Park, Basseterre | 2014 |
| 405 | 12 | St Lucia Kings v Guyana Amazon Warriors | Daren Sammy National Cricket Stadium, Gros Islet | 2025 |
| 391 | 17 | Guyana Amazon Warriors v Barbados Royals | Guyana National Stadium, Providence | 2024 |
| 389 | 9 | Guyana Amazon Warriors v St Lucia Kings | Guyana National Stadium, Providence | 2022 |
| 386 | 17 | Guyana Amazon Warriors v Jamaica Tallawahs | Warner Park, Basseterre | 2023 |
| 383 | 9 | Guyana Amazon Warriors v St Lucia Zouks | Warner Park, Basseterre | 2014 |
| 379 | 14 | Guyana Amazon Warriors v St Lucia Kings | Guyana National Stadium, Providence | 2024 |
| 378 | 11 | Barbados Royals v Guyana Amazon Warriors | Kensington Oval, Bridgetown | 2024 |
| 364 | 13 | Guyana Amazon Warriors v Barbados Royals | Guyana National Stadium, Providence | 2023 |
| 359 | 11 | Trinidad and Tobago Red Steel v Guyana Amazon Warriors | Queen's Park Oval, Port of Spain | 2014 |
| 359 | 12 | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Warner Park, Basseterre | 2021 |
| 359 | 17 | Barbados Royals v Guyana Amazon Warriors | Brian Lara Stadium, Tarouba | 2023 |
| 355 | 16 | Jamaica Tallawahs v Guyana Amazon Warriors | Sabina Park, Kingston | 2019 |
| 353 | 12 | Guyana Amazon Warriors v Trinbago Knight Riders | Guyana National Stadium, Providence | 2023 |
| 351 | 11 | Trinbago Knight Riders v Guyana Amazon Warriors | Queen's Park Oval, Port of Spain | 2019 |
| 350 | 8 | Guyana Amazon Warriors v Jamaica Tallawahs | Guyana National Stadium, Providence | 2018 |
| 348 | 15 | Guyana Amazon Warriors v Trinbago Knight Riders | Guyana National Stadium, Providence | 2024 |
| 347 | 17 | Guyana Amazon Warriors v Jamaica Tallawahs | Central Broward Regional Park Stadium Turf Ground, Lauderhill | 2018 |
| 347 | 12 | Trinbago Knight Riders v Guyana Amazon Warriors | Queen's Park Oval, Port of Spain | 2023 |
| 344 | 18 | Guyana Amazon Warriors v Jamaica Tallawahs | Guyana National Stadium, Providence | 2022 |
| 340 | 12 | Guyana Amazon Warriors v Barbados Tridents | Guyana National Stadium, Providence | 2018 |
| 339 | 9 | Barbados Tridents v Guyana Amazon Warriors | Kensington Oval, Bridgetown | 2014 |
| 339 | 13 | Antigua and Barbuda Falcons v Guyana Amazon Warriors | Sir Vivian Richards Stadium, North Sound | 2024 |
| 339 | 13 | Antigua and Barbuda Falcons v Guyana Amazon Warriors | Sir Vivian Richards Stadium, North Sound | 2025 |
| 337 | 13 | Guyana Amazon Warriors v Jamaica Tallawahs | Brian Lara Stadium, Tarouba | 2017 |
| 337 | 13 | St Kitts and Nevis Patriots v Guyana Amazon Warriors | Warner Park, Basseterre | 2018 |
| 337 | 8 | Guyana Amazon Warriors v St Lucia Kings | Guyana National Stadium, Providence | 2023 |
