| Runs |
Out of |
4s |
6s |
| 86 | 111 | 11 | 7 | | WJ Durston | Derbyshire v Nottinghamshire | Trent Bridge, Nottingham | 2010 |
| 76 | 104 | 13 | 4 | | CS MacLeod | Derbyshire v Northamptonshire | County Ground, Northampton | 2018 |
| 72 | 109* | 12 | 4 | | WL Madsen | Derbyshire v Leicestershire | Uptonsteel County Ground, Leicester | 2023 |
| 72 | 110* | 12 | 4 | | TA Wood | Derbyshire v Leicestershire | The Incora County Ground, Derby | 2023 |
| 72 | 94 | 9 | 6 | | LE Bosman | Derbyshire v Yorkshire | Headingley, Leeds | 2010 |
| 74 | 85 | 8 | 7 | | AHT Donald | Derbyshire v Yorkshire | Queen's Park, Chesterfield | 2025 |
| 60 | 100* | 12 | 2 | | GM Smith | Derbyshire v Yorkshire | Headingley, Leeds | 2008 |
| 64 | 86* | 10 | 4 | | WL Madsen | Derbyshire v Nottinghamshire | Trent Bridge, Nottingham | 2017 |
| 64 | 97* | 10 | 4 | | LM Reece | Derbyshire v Lancashire | The 3aaa County Ground, Derby | 2017 |
| 62 | 100* | 11 | 3 | | WL Madsen | Derbyshire v Durham | The Incora County Ground, Derby | 2022 |
| 68 | 71 | 8 | 6 | | AHT Donald | Derbyshire v Northamptonshire | County Ground, Northampton | 2025 |
| 62 | 83 | 8 | 5 | | J Moss | Derbyshire v Yorkshire | Headingley, Leeds | 2005 |
| 60 | 88 | 9 | 4 | | WJ Durston | Derbyshire v Leicestershire | The 3aaa County Ground, Derby | 2015 |
| 60 | 83* | 9 | 4 | | SR Patel | Derbyshire v Northamptonshire | The Central Co-op County Ground, Derby | 2025 |
| 60 | 90 | 6 | 6 | | MJ North | Derbyshire v Leicestershire | Grace Road, Leicester | 2014 |
| 50 | 89 | 11 | 1 | | WJ Durston | Derbyshire v Leicestershire | Queen's Park, Chesterfield | 2014 |
| 52 | 66 | 10 | 2 | | WL Madsen | Derbyshire v Yorkshire | Emerald Headingley Cricket Stadium, Leeds | 2018 |
| 50 | 73 | 11 | 1 | | Shan Masood | Derbyshire v Leicestershire | The Incora County Ground, Derby | 2022 |
| 52 | 73 | 10 | 2 | | WL Madsen | Derbyshire v Northamptonshire | The Incora County Ground, Derby | 2022 |
| 52 | 70 | 10 | 2 | | WL Madsen | Derbyshire v Lancashire | The Incora County Ground, Derby | 2022 |
| 48 | 71* | 12 | 0 | | WL Madsen | Derbyshire v Warwickshire | The Incora County Ground, Derby | 2023 |
| 56 | 84 | 8 | 4 | | AHT Donald | Derbyshire v Yorkshire | Headingley, Leeds | 2024 |
| 58 | 73 | 7 | 5 | | AHT Donald | Derbyshire v Nottinghamshire | Trent Bridge, Nottingham | 2025 |
| 52 | 77* | 10 | 2 | | WL Madsen | Derbyshire v Worcestershire | The Central Co-op County Ground, Derby | 2025 |
| 44 | 67 | 11 | 0 | | MJ Di Venuto | Derbyshire v Yorkshire | Headingley, Leeds | 2003 |
| 46 | 68 | 10 | 1 | | GM Smith | Derbyshire v Yorkshire | Queen's Park, Chesterfield | 2008 |
| 50 | 58 | 8 | 3 | | CJL Rogers | Derbyshire v Leicestershire | Grace Road, Leicester | 2009 |
| 46 | 75* | 10 | 1 | | LM Reece | Derbyshire v Northamptonshire | County Ground, Northampton | 2017 |
| 46 | 92 | 10 | 1 | | BA Godleman | Derbyshire v Worcestershire | The Pattonair County Ground, Derby | 2019 |
| 46 | 68 | 10 | 1 | | WL Madsen | Derbyshire v Nottinghamshire | Trent Bridge, Nottingham | 2020 |
| 50 | 92 | 8 | 3 | | JL du Plooy | Derbyshire v Lancashire | The Incora County Ground, Derby | 2021 |
| 48 | 61 | 9 | 2 | | WL Madsen | Derbyshire v Nottinghamshire | Trent Bridge, Nottingham | 2023 |
| 60 | 68 | 3 | 8 | | AHT Donald | Derbyshire v Northamptonshire | The Incora County Ground, Derby | 2024 |
| 48 | 67* | 9 | 2 | | SR Patel | Derbyshire v Leicestershire | Uptonsteel County Ground, Leicester | 2024 |
| 52 | 60 | 7 | 4 | | AHT Donald | Derbyshire v Leicestershire | Edgbaston, Birmingham | 2025 |
