| 269 runs | v Natal Country Districts | Addison Park, Empangeni | 1990/91 | a6777 |
| 244 runs | v South Africa African XI | St George's Park, Port Elizabeth | 1976/77 | a1823 |
| 226 runs | v Northern Transvaal Country Districts | Pietersburg Cricket Club A Ground, Pietersburg | 1992/93 | a7774 |
| 208 runs | v KwaZulu-Natal Coastal | St George's Park, Gqeberha | 2021/22 | a28941 |
| 206 runs | v Border | Jan Smuts Ground, East London | 1974/75 | a1302 |
| 180 runs | v Southern Cape | Recreation Ground, Oudtshoorn | 1989/90 | a6282 |
| 179 runs | v Griqualand West | De Beers Stadium, Kimberley | 1972/73 | a844 |
| 174 runs | v Orange Free State | St George's Park, Port Elizabeth | 1971/72 | a624 |
| 171 runs | v Impalas | St George's Park, Port Elizabeth | 1991/92 | a7461 |
| 151 runs | v South Western Districts | Sahara Oval St George's, Port Elizabeth | 2006/07 | a17690 |
| 147 runs | v Free State | St George's Park, Port Elizabeth | 1998/99 | a11715 |
| 134 runs | v Griqualand West | Kimberley Country Club, Kimberley | 1994/95 | a9076 |
| 128 runs | v Western Province | New Wanderers Stadium, Johannesburg | 1975/76 | a1595 |
| 126 runs | v KwaZulu-Natal Inland | City Oval, Pietermaritzburg | 2015/16 | a24359 |
| 126 runs | v KwaZulu-Natal Coastal | Hollywoodbets Kingsmead, Durban | 2024/25 | a31499 |
| 125 runs | v Rhodesia | St George's Park, Port Elizabeth | 1975/76 | a1579 |
| 125 runs | v Impalas | St George's Park, Port Elizabeth | 1985/86 | a4752 |
| 124 runs | v Gauteng | Bidvest Wanderers Stadium, Johannesburg | 2014/15 | a23545 |
| 121 runs | v Northern Transvaal | Berea Park, Pretoria | 1973/74 | a1065 |
| 121 runs | v North West | JB Marks Cricket Oval, Potchefstroom | 2024/25 | a31543 |
| 117 runs | v Griqualand West | Axxess DSL St George's, Port Elizabeth | 2009/10 | a20160 |
| 116 runs | v Impalas | St George's Park, Port Elizabeth | 1991/92 | a7467 |
| 113 runs | v Western Province | St George's Park, Port Elizabeth | 1989/90 | a6331 |
| 109 runs | v Zimbabwe Under-23s | Pollock Field, Grey High School Ground, Port Elizabeth | 2005/06 | a16923 |
| 109 runs | v Northerns | St George's Park, Gqeberha | 2023/24 | a30260 |
| 108 runs | v Orange Free State | Ramblers Cricket Club Ground, Bloemfontein | 1977/78 | a2065 |
| 102 runs | v KwaZulu-Natal | Sahara Oval St George's, Port Elizabeth | 2007/08 | a18714 |
| 101 runs | v Transvaal | St George's Park, Port Elizabeth | 1972/73 | a862 |
