Largest Margin of Runs Defeat
| 228 runs | by West Indies | Lord's Cricket Ground, St John's Wood | 2012 | a22012 |
| 214 runs | by Northamptonshire | Lord's Cricket Ground, St John's Wood | 2002 | a14450 |
| 166 runs | by Kent | St Lawrence Ground, Canterbury | 1993 | a8093 |
| 160 runs | by Leicestershire | Grace Road, Leicester | 1998 | a11357 |
| 152 runs | by Somerset | Lord's Cricket Ground, St John's Wood | 1996 | a9798 |
| 144 runs | by Hampshire | Lord's Cricket Ground, St John's Wood | 1998 | a11310 |
| 141 runs | by Bangladeshis | Lord's Cricket Ground, St John's Wood | 2010 | a20647 |
| 132 runs | by Sussex | County Ground, Hove | 2004 | a16114 |
| 130 runs | by Sussex | County Ground, Hove | 1971 | a562 |
| 125 runs | by Yorkshire | Headingley, Leeds | 1974 | a1196 |
| 125 runs | by Surrey | Kennington Oval, Kennington | 1982 | a3437 |
| 121 runs | by Glamorgan | Sophia Gardens, Cardiff | 1993 | a8112 |
| 114 runs | by Surrey | Kennington Oval, Kennington | 1964 | a35 |
| 108 runs | by Warwickshire | Edgbaston, Birmingham | 1997 | a10534 |
| 105 runs | by Hampshire | Lord's Cricket Ground, St John's Wood | 2005 | a16624 |
| 103 runs | by Kent | St Lawrence Ground, Canterbury | 1987 | a5257 |
| 103 runs | by Worcestershire | County Ground, New Road, Worcester | 1991 | a7181 |
| 101 runs | by Sussex | County Ground, Hove | 1986 | a4985 |
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