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Most Runs in a Match against Middlesex
| 370 | CM Spearman | for Gloucestershire | Archdeacon Meadow, Gloucester | 2004 | f48013 |
| 355 | DW Randall | for Nottinghamshire | Trent Bridge, Nottingham | 1979 | f32746 |
| 326 | MR Ramprakash | for Surrey | The Brit Oval, Kennington | 2010 | f52434 |
| 316 | JB Hobbs | for Surrey | Lord's Cricket Ground, St John's Wood | 1926 | f11773 |
| 315 | P Holmes | for Yorkshire | Lord's Cricket Ground, St John's Wood | 1925 | f11222 |
| 315 | MA Wagh | for Warwickshire | Lord's Cricket Ground, St John's Wood | 2001 | f45992 |
| 315 | JL Langer | for Somerset | County Ground, Taunton | 2007 | f50021 |
| 312 | WW Keeton | for Nottinghamshire | Kennington Oval, Kennington | 1939 | f16615 |
| 305 | MJ Di Venuto | for Derbyshire | Lord's Cricket Ground, St John's Wood | 2002 | f46727 |
| 303 | NV Knight | for Warwickshire | Lord's Cricket Ground, St John's Wood | 2004 | f48005 |
| 297 | KS Duleepsinhji | for Cambridge University | FP Fenner's Ground, Cambridge | 1927 | f11879 |
| 295 | PR Johnson | for Somerset | County Ground, Taunton | 1908 | f7523 |
| 294 | J Hardstaff | for Nottinghamshire | Trent Bridge, Nottingham | 1937 | f15949 |
| 294 | AA Metcalfe | for Yorkshire | Headingley, Leeds | 1988 | f37691 |
| 286 | TR Ward | for Kent | St Lawrence Ground, Canterbury | 1991 | f39501 |
| 284 | JT Brown | for Yorkshire | Lord's Cricket Ground, St John's Wood | 1896 | f4420 |
| 283 | EH Bowley | for Sussex | County Ground, Hove | 1933 | f14371 |
| 282 | KC Wessels | for Sussex | County Ground, Hove | 1980 | f33215 |
| 281 | KJ Key | for Oxford University | Chiswick Park, Chiswick | 1887 | f3146 |
| 278 | IR Bell | for Warwickshire | Edgbaston, Birmingham | 2005 | f48650 |
| 277 | BC Lara | for Warwickshire | Lord's Cricket Ground, St John's Wood | 1998 | f43813 |
| 276 | RJ Bailey | for Northamptonshire | Uxbridge Cricket Club Ground, Uxbridge | 1995 | f41891 |
| 274 | FE Woolley | for Kent | St Lawrence Ground, Canterbury | 1923 | f10685 |
| 269 | DS Sheppard | for Cambridge University | FP Fenner's Ground, Cambridge | 1951 | f19151 |
| 267 | A Shrewsbury | for Nottinghamshire | Trent Bridge, Nottingham | 1887 | f3183 |
| 265 | AD Brown | for Surrey | Lord's Cricket Ground, St John's Wood | 1999 | f44558 |
| 263 | M Tompkin | for Leicestershire | Grace Road, Leicester | 1952 | f19555 |
| 263 | RE Marshall | for Hampshire | Lord's Cricket Ground, St John's Wood | 1970 | f28175 |
| 263 | VJ Wells | for Leicestershire | Lord's Cricket Ground, St John's Wood | 1997 | f43102 |
| 261 | CJ Adams | for Derbyshire | County Ground, Derby | 1996 | f42461 |
| 259 | GA Gooch | for Essex | County Ground, Chelmsford | 1991 | f39524 |
| 258 | PCL Holloway | for Somerset | Uxbridge Cricket Club Ground, Uxbridge | 1996 | f42575 |
| 256 | WL Madsen | for Derbyshire | Uxbridge Cricket Club Ground, Uxbridge | 2009 | f51740 |
| 254 | RT Spooner | for Warwickshire | Lord's Cricket Ground, St John's Wood | 1951 | f19136 |
| 254 | KP Pietersen | for Nottinghamshire | Trent Bridge, Nottingham | 2002 | f46722 |
| 252 | MR Ramprakash | for Surrey | The Brit Oval, Kennington | 2005 | f48825 |
| 251 | ML Love | for Durham | Lord's Cricket Ground, St John's Wood | 2002 | f46641 |
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