| Runs |
Out of |
4s |
6s |
| 84 | 122 | 15 | 4 | | Babar Azam | Pakistan v South Africa | SuperSport Park, Centurion | 2020/21 |
| 74 | 110* | 11 | 5 | | Babar Azam | Pakistan v England | National Bank Cricket Arena, Karachi | 2022/23 |
| 70 | 111* | 10 | 5 | | Ahmed Shehzad | Pakistan v Bangladesh | Shere Bangla National Stadium, Mirpur | 2013/14 |
| 66 | 83 | 12 | 3 | | Mukhtar Ahmed | Pakistan v Zimbabwe | Gaddafi Stadium, Lahore | 2015 |
| 66 | 91 | 12 | 3 | | Fakhar Zaman | Pakistan v Australia | Harare Sports Club, Harare | 2018 |
| 70 | 99* | 10 | 5 | | Mohammad Hafeez | Pakistan v New Zealand | Seddon Park, Hamilton | 2020/21 |
| 58 | 97* | 13 | 1 | | Babar Azam | Pakistan v West Indies | National Stadium, Karachi | 2017/18 |
| 58 | 90 | 13 | 1 | | Babar Azam | Pakistan v South Africa | Bidvest Wanderers Stadium, Johannesburg | 2018/19 |
| 62 | 101* | 11 | 3 | | Babar Azam | Pakistan v New Zealand | Gaddafi Stadium, Lahore | 2023 |
| 60 | 86 | 9 | 4 | | Mohammad Hafeez | Pakistan v South Africa | SuperSport Park, Centurion | 2012/13 |
| 60 | 94 | 9 | 4 | | Umar Akmal | Pakistan v Australia | Shere Bangla National Stadium, Mirpur | 2013/14 |
| 58 | 89* | 10 | 3 | | Sarfraz Ahmed | Pakistan v Scotland | Raeburn Place, Edinburgh | 2018 |
| 58 | 89 | 10 | 3 | | Mohammad Rizwan | Pakistan v New Zealand | McLean Park, Napier | 2020/21 |
| 66 | 104* | 6 | 7 | | Mohammad Rizwan | Pakistan v South Africa | Gaddafi Stadium, Lahore | 2020/21 |
| 58 | 87 | 10 | 3 | | Mohammad Rizwan | Pakistan v West Indies | National Stadium, Karachi | 2021/22 |
| 54 | 72 | 9 | 3 | | Imran Nazir | Pakistan v Bangladesh | Pallekele Cricket Stadium, Pallekele | 2012/13 |
| 60 | 98* | 6 | 6 | | Ahmed Shehzad | Pakistan v Zimbabwe | Harare Sports Club, Harare | 2013 |
| 52 | 86 | 10 | 2 | | Babar Azam | Pakistan v World XI | Gaddafi Stadium, Lahore | 2017/18 |
| 54 | 73 | 9 | 3 | | Fakhar Zaman | Pakistan v Australia | Harare Sports Club, Harare | 2018 |
| 56 | 79* | 8 | 4 | | Mohammad Rizwan | Pakistan v Namibia | Sheikh Zayed Stadium, Abu Dhabi | 2021/22 |
| 50 | 89 | 8 | 3 | | Ahmed Shehzad | Pakistan v World XI | Gaddafi Stadium, Lahore | 2017/18 |
| 48 | 74* | 9 | 2 | | Mohammad Rizwan | Pakistan v South Africa | Imperial Wanderers Stadium, Johannesburg | 2020/21 |
| 46 | 82* | 10 | 1 | | Mohammad Rizwan | Pakistan v Zimbabwe | Harare Sports Club, Harare | 2020/21 |
| 50 | 85 | 8 | 3 | | Babar Azam | Pakistan v England | Trent Bridge, Nottingham | 2021 |
| 48 | 79 | 9 | 2 | | Babar Azam | Pakistan v West Indies | National Stadium, Karachi | 2021/22 |
| 44 | 79* | 11 | 0 | | Babar Azam | Pakistan v New Zealand | Hagley Oval, Christchurch | 2022/23 |
| 52 | 98* | 7 | 4 | | Mohammad Rizwan | Pakistan v New Zealand | Rawalpindi Cricket Stadium, Rawalpindi | 2023 |
| 44 | 73 | 8 | 2 | | Salman Butt | Pakistan v Bangladesh | Beausejour Stadium, Gros Islet | 2010 |
| 46 | 64 | 7 | 3 | | Umar Akmal | Pakistan v Australia | Edgbaston, Birmingham | 2010 |
| 40 | 54 | 10 | 0 | | Ahmed Shehzad | Pakistan v New Zealand | AMI Stadium, Christchurch | 2010/11 |
| 44 | 76* | 8 | 2 | | Sarfraz Ahmed | Pakistan v New Zealand | Dubai Sports City Stadium, Dubai | 2014/15 |
| 44 | 75 | 8 | 2 | | Shoaib Malik | Pakistan v England | Sharjah Cricket Association Stadium, Sharjah | 2015/16 |
| 44 | 61 | 8 | 2 | | Mohammad Hafeez | Pakistan v New Zealand | Eden Park, Auckland | 2015/16 |
| 46 | 63* | 7 | 3 | | Shoaib Malik | Pakistan v United Arab Emirates | Shere Bangla National Stadium, Mirpur | 2015/16 |
| 42 | 47 | 9 | 1 | | Sharjeel Khan | Pakistan v New Zealand | Punjab Cricket Association IS Bindra Stadium, Mohali | 2015/16 |
| 44 | 59* | 8 | 2 | | Khalid Latif | Pakistan v England | Emirates Old Trafford, Manchester | 2016 |
| 46 | 59 | 7 | 3 | | Sharjeel Khan | Pakistan v England | Emirates Old Trafford, Manchester | 2016 |
| 42 | 67* | 9 | 1 | | Mohammad Hafeez | Pakistan v Bangladesh | Gaddafi Stadium, Lahore | 2019/20 |
| 52 | 86* | 4 | 6 | | Mohammad Hafeez | Pakistan v England | Emirates Old Trafford, Manchester | 2020 |
| 42 | 82 | 9 | 1 | | Babar Azam | Pakistan v Zimbabwe | Rawalpindi Cricket Stadium, Rawalpindi | 2020/21 |
| 48 | 68 | 6 | 4 | | Haider Ali | Pakistan v West Indies | National Stadium, Karachi | 2021/22 |
| 40 | 78 | 10 | 0 | | Mohammad Rizwan | Pakistan v West Indies | National Stadium, Karachi | 2021/22 |
| 42 | 88 | 9 | 1 | | Mohammad Rizwan | Pakistan v England | National Bank Cricket Arena, Karachi | 2022/23 |
| 46 | 87* | 7 | 3 | | Babar Azam | Pakistan v England | Gaddafi Stadium, Lahore | 2022/23 |
