| 106* | DA Miller | South Africa v India | Nehru Stadium, Guwahati | 2022/23 |
| 100* | RR Rossouw | South Africa v India | Holkar Stadium, Indore | 2022/23 |
| 81 | H Klaasen | South Africa v India | Barabati Stadium, Cuttack | 2022 |
| 79* | Q de Kock | South Africa v India | M Chinnaswamy Stadium, Bangalore | 2019/20 |
| 78 | CA Ingram | South Africa v India | Bidvest Wanderers Stadium, Johannesburg | 2011/12 |
| 75* | HE van der Dussen | South Africa v India | Feroz Shah Kotla, Delhi | 2022 |
| 73 | JH Kallis | South Africa v India | Beausejour Stadium, Gros Islet | 2010 |
| 70 | RR Hendricks | South Africa v India | Bidvest Wanderers Stadium, Johannesburg | 2017/18 |
| 69 | H Klaasen | South Africa v India | SuperSport Park, Centurion | 2017/18 |
| 69* | Q de Kock | South Africa v India | Nehru Stadium, Guwahati | 2022/23 |
| 68* | JP Duminy | South Africa v India | Himachal Pradesh Cricket Association Stadium, Dharamsala | 2015/16 |
| 68 | Q de Kock | South Africa v India | Holkar Stadium, Indore | 2022/23 |
| 67 | MN van Wyk | South Africa v India | Moses Mabhida Stadium, Durban | 2010/11 |
| 65 | F du Plessis | South Africa v India | R Premadasa Stadium, Colombo | 2012/13 |
| 64* | JP Duminy | South Africa v India | SuperSport Park, Centurion | 2017/18 |
| 64* | DA Miller | South Africa v India | Feroz Shah Kotla, Delhi | 2022 |
| 63 | AB de Villiers | South Africa v India | Trent Bridge, Nottingham | 2009 |
| 61 | JH Kallis | South Africa v India | Bidvest Wanderers Stadium, Johannesburg | 2011/12 |
| 59* | DA Miller | South Africa v India | Optus Stadium, Perth | 2022/23 |
| 58 | F du Plessis | South Africa v India | Shere Bangla National Stadium, Mirpur | 2013/14 |
| 55 | JP Duminy | South Africa v India | PPC Newlands, Cape Town | 2017/18 |
| 52 | Q de Kock | South Africa v India | Punjab Cricket Association IS Bindra Stadium, Mohali | 2019/20 |
| 52 | AK Markram | South Africa v India | Optus Stadium, Perth | 2022/23 |
| 51 | AB de Villiers | South Africa v India | Himachal Pradesh Cricket Association Stadium, Dharamsala | 2015/16 |
| 49 | C Jonker | South Africa v India | PPC Newlands, Cape Town | 2017/18 |
| 49 | T Bavuma | South Africa v India | Punjab Cricket Association IS Bindra Stadium, Mohali | 2019/20 |
| 49 | RR Hendricks | South Africa v India | St George's Park, Gqeberha | 2023/24 |
| 45* | JP Duminy | South Africa v India | Shere Bangla National Stadium, Mirpur | 2013/14 |
| 41 | KA Maharaj | South Africa v India | Greenfield Stadium, Karyavattom | 2022/23 |
| 39 | F Behardien | South Africa v India | Bidvest Wanderers Stadium, Johannesburg | 2017/18 |
